IgE production from the nasal polyp tissue: comparison between atopic and non-atopic subjects
The Korean Journal of Internal Medicine
;
: 83-87, 1998.
Article
in English
| WPRIM
| ID: wpr-110300
ABSTRACT
OBJECTIVES AND METHODS:
To confirm the local production of IgE antibody from the nasal polyp tissue, and to evaluate the difference between atopics and non-atopics, nasal polyp tissues were taken from both 10 atopic and 10 non-atopic subjects. The tissue total IgE (tlgE) level was measured by enzyme-linked immunosorbent assay (ELISA) and serum tlgE level by radio-immunoassay. The tissue albumin level was measured by nephelometry, and serum albumin level by Bromocresol green method.RESULTS:
The polyp tissue tlgE/albumin as well as serum tlgE/albumin ratio were significantly higher in atopics than in non-atopics (p 0.05). Three non-atopic subjects had high polyp tissue tlgE/albumin (> 10). A significant correlation was noted between serum tlgE/albumin and polyp tlgE/albumin (r = 0.46, p = 0.04). The ratio of polyp tlgE/albumin to serum tlgE/albumin was greater than 1 in all of the non-atopic subjects and 7 of 10 atopic subjects.CONCLUSION:
These findings support the hypothesis that IgE antibody could be locally produced from the nasal polyp tissue of non-atopic subjects as well as atopic subjects. The possibility of an isolated local production of IgE antibody was suggested.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Values
/
Biopsy, Needle
/
Immunoglobulin E
/
Enzyme-Linked Immunosorbent Assay
/
Radioimmunoassay
/
Comparative Study
/
Nasal Polyps
/
Antibodies, Anti-Idiotypic
/
Culture Techniques
/
Albumins
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
1998
Type:
Article
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