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IgE production from the nasal polyp tissue: comparison between atopic and non-atopic subjects
The Korean Journal of Internal Medicine ; : 83-87, 1998.
Article in English | WPRIM | ID: wpr-110300
ABSTRACT
OBJECTIVES AND

METHODS:

To confirm the local production of IgE antibody from the nasal polyp tissue, and to evaluate the difference between atopics and non-atopics, nasal polyp tissues were taken from both 10 atopic and 10 non-atopic subjects. The tissue total IgE (tlgE) level was measured by enzyme-linked immunosorbent assay (ELISA) and serum tlgE level by radio-immunoassay. The tissue albumin level was measured by nephelometry, and serum albumin level by Bromocresol green method.

RESULTS:

The polyp tissue tlgE/albumin as well as serum tlgE/albumin ratio were significantly higher in atopics than in non-atopics (p 0.05). Three non-atopic subjects had high polyp tissue tlgE/albumin (> 10). A significant correlation was noted between serum tlgE/albumin and polyp tlgE/albumin (r = 0.46, p = 0.04). The ratio of polyp tlgE/albumin to serum tlgE/albumin was greater than 1 in all of the non-atopic subjects and 7 of 10 atopic subjects.

CONCLUSION:

These findings support the hypothesis that IgE antibody could be locally produced from the nasal polyp tissue of non-atopic subjects as well as atopic subjects. The possibility of an isolated local production of IgE antibody was suggested.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Reference Values / Biopsy, Needle / Immunoglobulin E / Enzyme-Linked Immunosorbent Assay / Radioimmunoassay / Comparative Study / Nasal Polyps / Antibodies, Anti-Idiotypic / Culture Techniques / Albumins Limits: Female / Humans / Male Language: English Journal: The Korean Journal of Internal Medicine Year: 1998 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Reference Values / Biopsy, Needle / Immunoglobulin E / Enzyme-Linked Immunosorbent Assay / Radioimmunoassay / Comparative Study / Nasal Polyps / Antibodies, Anti-Idiotypic / Culture Techniques / Albumins Limits: Female / Humans / Male Language: English Journal: The Korean Journal of Internal Medicine Year: 1998 Type: Article