Relationships between Serum Adiponectin with Metabolic Syndrome and Components of Metabolic Syndrome in Non-Diabetic Koreans: ARIRANG Study
Yonsei Medical Journal
;
: 234-241, 2011.
Article
in English
| WPRIM
| ID: wpr-110479
ABSTRACT
PURPOSE:
Growing evidence suggests that hypoadiponectinemia may play a significant role in the development of metabolic syndrome (MetS). Therefore, the relationships between serum adiponectin with MetS and components of MetS were investigated in non-diabetic samples of drawn from the Koreans general population. MATERIALS ANDMETHODS:
We performed a cross-sectional study in samples of older Koreans (age > 40 years) including 2,471 men and 3,463 women. MetS was defined according to the Asian modified criteria of the National Cholesterol Education Program Adult Treatment Panel III report. Serum adiponectin concentrations were measured by radioimmunoassay.RESULTS:
The median adiponectin level in MetS was significantly lower than that in non-MetS subjects in men (6.00 vs. 8.00 microg/mL, p < 0.001) and women (10.12 vs. 11.74 microg/mL, p < 0.001). Adiponectin concentration was negatively correlated with waist circumference and levels of triglyceride, C-reactive protein (CRP), fasting glucose, and insulin, and positively correlated with high-density lipoprotein and age in both genders (p < 0.001). In a multivariate regression model after adjustment for age, body mass index, smoking, CRP, and lipid profiles, the odds ratio of MetS comparing extreme quartiles of adiponectin distribution was 0.32 [95% confidence interval (CI), 0.20 to 0.50] in men and 0.57 (95% CI, 0.43 to 0.76) in women.CONCLUSION:
Adiponectin levels are independently associated with the phenotype of MetS, as well as components of MetS in the non-diabetic Korean general population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sex Ratio
/
Triglycerides
/
Blood Glucose
/
C-Reactive Protein
/
Body Mass Index
/
Odds Ratio
/
Cross-Sectional Studies
/
Multivariate Analysis
/
Metabolic Syndrome
/
Adiponectin
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Yonsei Medical Journal
Year:
2011
Type:
Article
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