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Clinicopathological Features and Surgical Safety of Gastric Cancer in Elderly Patients
Article in En | WPRIM | ID: wpr-110668
Responsible library: WPRO
ABSTRACT
Gastric cancer is one of the most common cancers, especially among the elderly. However little is known about gastric cancer in elderly patients. This study was designed to evaluate the specific features of gastric cancer in elderly patients. Medical records of 1,107 patients who had radical gastrectomy for gastric cancer between June 2005 and December 2009 were reviewed. They were divided into young ( or =75 yr, n=99). Increased CA 19-9 (5.6%, 13.4%, 14.6%, P=0.001), advanced diseases (42.5%, 47.0%, and 57.6, P=0.014), and node metastasis (37.6%, 38.9%, 51.5%, P=0.029) were more common in the young-old and old-old age groups. There were no significant differences in Helicobacter pylori status (63.6%, 56.7%, 61.2%, P=0.324) between the three groups. Surgery-related complication rates were similar in the three groups (5.3%, 5.1%, 8.1%, P=0.497). Microsatellite instability (P<0.001) and p53 overexpression (P<0.001) were more common among the elderly. The elderly group had more synchronous tumors (7.5%, 10.2%, 17.2%; P=0.006). Surgery can be applied to elderly gastric cancer without significant risk of complications. However, considering the more advanced disease and synchronous tumors among the elderly, care should be taken while deciding the extent of surgery for elderly gastric cancer.
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Full text: 1 Index: WPRIM Main subject: Postoperative Complications / Stomach Neoplasms / Comorbidity / Prevalence / Causality / Risk Factors / Treatment Outcome / Sex Distribution / Age Distribution / Republic of Korea Type of study: Etiology_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Journal of Korean Medical Science Year: 2014 Type: Article
Full text: 1 Index: WPRIM Main subject: Postoperative Complications / Stomach Neoplasms / Comorbidity / Prevalence / Causality / Risk Factors / Treatment Outcome / Sex Distribution / Age Distribution / Republic of Korea Type of study: Etiology_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Journal of Korean Medical Science Year: 2014 Type: Article