Expression of neurotrophic factors in injured spinal cord after transplantation of human-umbilical cord blood stem cells in rats
Journal of Veterinary Science
;
: 97-102, 2016.
Article
in English
| WPRIM
| ID: wpr-110760
ABSTRACT
We induced percutaneous spinal cord injuries (SCI) using a balloon catheter in 45 rats and transplanted human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) at the injury site. Locomotor function was significantly improved in hUCB-MSCs transplanted groups. Quantitative ELISA of extract from entire injured spinal cord showed increased expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3). Our results show that treatment of SCI with hUCB-MSCs can improve locomotor functions, and suggest that increased levels of BDNF, NGF and NT-3 in the injured spinal cord were the main therapeutic effect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spinal Cord Injuries
/
Enzyme-Linked Immunosorbent Assay
/
Gene Expression Regulation
/
Brain-Derived Neurotrophic Factor
/
Nerve Growth Factor
/
Gene Expression Profiling
/
Cord Blood Stem Cell Transplantation
/
Locomotion
Limits:
Animals
/
Humans
Language:
English
Journal:
Journal of Veterinary Science
Year:
2016
Type:
Article
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