Immunohistochemical Expression of CXC Chemokine Receptor 4 and Galectin-3 in Follicular Tumors of Thyroid / 대한갑상선학회지
Journal of Korean Thyroid Association
;
: 45-51, 2012.
Article
in Korean
| WPRIM
| ID: wpr-111464
ABSTRACT
BACKGROUND AND OBJECTIVES:
Follicular tumors can present a difficult diagnostic challenge for cytological evaluation and ultrasound findings. Therefore, new methods which could help distinguish follicular adenoma from follicular carcinoma simply and accurately are greatly desired. This study investigated the usefulness of immnunohistochemical expression of CXC chemokine receptor 4 (CXCR4) and galectin-3 as marker of differentiated thyroid carcinomas. MATERIALS ANDMETHODS:
Expression of CXCR4 and galectin-3 were examined immunohistochemically in the 60 paraffin embedded tissues which were already diagnosed as follicular adenoma (n=20), follicullar carcinoma (n=20), and papillary carcinoma (n=20) of thyroid.RESULTS:
Galatin-3 was expressed significantly high in follicular carcinoma than follicular adenoma (p=0.022). CXCR4 was also expressed significantly high in follicular carcinoma than follicular adenoma (p=0.027). The sensitivity of CXCR4 and galectin-3 was 70% and 80% and specificity, 65% and 60% for differential diagnosis of follicular tumors.CONCLUSION:
An immunohistochemical panel, including galatin-3 and CXCR4, could be useful in the differential diagnosis between follicular adenoma from follicular carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraffin
/
Thyroid Gland
/
Carcinoma, Papillary
/
Adenoma
/
Sensitivity and Specificity
/
Receptors, CXCR4
/
Galectin 3
/
Diagnosis, Differential
/
Receptors, CXCR
Type of study:
Diagnostic study
Language:
Korean
Journal:
Journal of Korean Thyroid Association
Year:
2012
Type:
Article
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