Leptomeningeal carcinomatosis from gastric cancer: single institute retrospective analysis of 9 cases
Annals of Surgical Treatment and Research
;
: 16-21, 2014.
Article
in English
| WPRIM
| ID: wpr-111668
ABSTRACT
PURPOSE:
The aim of this study is to investigate the clinical features and outcomes of 9 consecutive patients who suffered with leptomeningeal carcinomatosis (LMC) originating from gastric cancer.METHODS:
Between January 1995 and December 2010, we retrospectively reviewed the medical records of 9 patients with gastric LMC who had been treated at St. Vincent's Hospital, The Catholic University of Korea.RESULTS:
With the exception of 1 patient, the primary gastric cancer was Borrmann type III or IV, and 5 cases had poorly differentiated or signet ring cell histology. TNM stage of the primary gastric cancer was III in 6 patients. The median interval from diagnosis of the primary malignancy to the diagnosis of LMC was 9 months. Headache (6 cases), altered mental status (4 cases), and dysarthria (3 cases) were presenting symptoms of LMC. Computed tomography findings were abnormal in 4 of 7 cases, while magnetic resonance imaging revealed abnormality in 4 of 5 cases. Radiation therapy was administered to 5 patients and intrathecal chemotherapy was administered to only 1 patient. Median overall survival duration from the diagnosis of LMC was 3 months.CONCLUSION:
LMC originating from gastric cancer had a fatal clinical course and treatment strategies remain challenging.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Stomach Neoplasms
/
Magnetic Resonance Imaging
/
Medical Records
/
Retrospective Studies
/
Diagnosis
/
Drug Therapy
/
Dysarthria
/
Meningeal Carcinomatosis
/
Headache
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Annals of Surgical Treatment and Research
Year:
2014
Type:
Article
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