Membranous Nephropathy in a 13-Year-Old Boy with Common Variable Immunodeficiency
Journal of Korean Medical Science
;
: 1436-1438, 2012.
Article
in English
| WPRIM
| ID: wpr-111759
ABSTRACT
Various forms of hypogammaglobulinemia can occur in patients with autoimmune diseases and vice versa. We report a 13-yr-old boy with membranous nephropathy and common variable immunodeficiency. He presented with the nephrotic syndrome, pneumonia with bronchiectasis, and profound hypogammaglobulinemia. Renal biopsy showed diffusely thickened glomerular capillary walls with 'spikes' suggesting a membranous nephropathy. Secondary causes were ruled out by laboratory studies; however, heavy proteinuria persisted with steroid therapy. Cyclosporine and intravenous immunoglobulin were added, and the patient was discharged with decreased proteinuria. Hypogammaglobulinemia may have a deleterious impact on the immune dysregulation in some patients with membranous nephropathy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Proteinuria
/
Steroids
/
Bronchiectasis
/
Immunoglobulins
/
Glomerulonephritis, Membranous
/
Cyclosporine
/
Common Variable Immunodeficiency
/
Drug Therapy, Combination
/
Immunosuppressive Agents
Limits:
Adolescent
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2012
Type:
Article
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