Neurosyphilis Mimicking Creutzfeldt-Jakob Disease
Dementia and Neurocognitive Disorders
;
: 170-173, 2016.
Article
in English
| WPRIM
| ID: wpr-111894
ABSTRACT
BACKGROUND:
As rapidly progressive dementia (RPD), general paresis and Creutzfeldt-Jakob disease (CJD) may have overlapping clinical presentation due to a wide variety of clinical manifestations. CASE REPORT A 57-year-old man presented with rapid progressive cognitive decline, behavioral change, ataxic gait, tremor and pyramidal signs for 3 months. In addition to these multiple systemic involvements, positive result for the cerebrospinal fluid (CSF) 14-3-3 protein tentatively diagnosed him as probable CJD. However, due to increased serum rapid plasma reagin, venereal disease research laboratory, and fluorescent treponemal antibody-absorption reactivity in CSF, the final diagnosis was changed to general paresis.CONCLUSIONS:
A patient with RPD needs to be carefully considered for differential diagnosis, among a long list of diseases. It is important to rule out CJD, which is the most frequent in RPD and is a fatal disease with no cure. Diagnostic criteria or marker of CJD, such as 14-3-3 protein, may be inconclusive, and a typical pattern in diffusion-weighted imaging is important to rule out other reversible diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Tremor
/
Sexually Transmitted Diseases
/
Cerebrospinal Fluid
/
Creutzfeldt-Jakob Syndrome
/
Dementia
/
14-3-3 Proteins
/
Diagnosis
/
Diagnosis, Differential
/
Gait
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Dementia and Neurocognitive Disorders
Year:
2016
Type:
Article
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