Chemopreventive Action of Anthocyanin-rich Black Soybean Fraction in APC(Min/+) Intestinal Polyposis Model
Journal of Cancer Prevention
;
: 193-201, 2015.
Article
in English
| WPRIM
| ID: wpr-112061
ABSTRACT
BACKGROUND:
Anthocyanins have been shown to inhibit cancer cell growth by suppressing oxidative stress and inflammatory responses. The purpose of this study was to investigate the effects of an anthocyanin-rich extract (AE) from black soybean coat on intestinal carcinogenesis.METHODS:
APC(Min/+) mice were fed a diet of 0.2% or 0.5% AE for 7 weeks. We analyzed the number of intestinal tumors, oxidative stress and inflammatory markers associated with beta-catenin and cytosolic phospholipase A2 (cPLA2) signals. The number of intestinal tumors, and cellular expression of beta-catenin were determined.RESULTS:
The number of intestinal tumors was significantly lower in mice fed a 0.5% AE diet compared to those of the other groups. Cytosolic beta-catenin expression was significantly decreased in the AE supplemented groups compared to that of the control animals. In addition, mucosa expression of cyclooxygenase-2 and cPLA2 were also significantly decreased in the 0.5% AE group, by 32% and 62%, respectively, compared to the control group.CONCLUSIONS:
These results suggest that dietary AE reduced the development of intestinal tumors, possibly through the ability to suppress oxidative stresses, decreasing inflammatory responses mediated by beta-catenin associated signals.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Soybeans
/
Oxidative Stress
/
Cytosol
/
Intestinal Polyposis
/
Diet
/
Cyclooxygenase 2
/
Beta Catenin
/
Phospholipases A2
/
Carcinogenesis
/
Inflammation
Limits:
Animals
Language:
English
Journal:
Journal of Cancer Prevention
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS