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Chemopreventive Action of Anthocyanin-rich Black Soybean Fraction in APC(Min/+) Intestinal Polyposis Model
Journal of Cancer Prevention ; : 193-201, 2015.
Article in English | WPRIM | ID: wpr-112061
ABSTRACT

BACKGROUND:

Anthocyanins have been shown to inhibit cancer cell growth by suppressing oxidative stress and inflammatory responses. The purpose of this study was to investigate the effects of an anthocyanin-rich extract (AE) from black soybean coat on intestinal carcinogenesis.

METHODS:

APC(Min/+) mice were fed a diet of 0.2% or 0.5% AE for 7 weeks. We analyzed the number of intestinal tumors, oxidative stress and inflammatory markers associated with beta-catenin and cytosolic phospholipase A2 (cPLA2) signals. The number of intestinal tumors, and cellular expression of beta-catenin were determined.

RESULTS:

The number of intestinal tumors was significantly lower in mice fed a 0.5% AE diet compared to those of the other groups. Cytosolic beta-catenin expression was significantly decreased in the AE supplemented groups compared to that of the control animals. In addition, mucosa expression of cyclooxygenase-2 and cPLA2 were also significantly decreased in the 0.5% AE group, by 32% and 62%, respectively, compared to the control group.

CONCLUSIONS:

These results suggest that dietary AE reduced the development of intestinal tumors, possibly through the ability to suppress oxidative stresses, decreasing inflammatory responses mediated by beta-catenin associated signals.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Soybeans / Oxidative Stress / Cytosol / Intestinal Polyposis / Diet / Cyclooxygenase 2 / Beta Catenin / Phospholipases A2 / Carcinogenesis / Inflammation Limits: Animals Language: English Journal: Journal of Cancer Prevention Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Soybeans / Oxidative Stress / Cytosol / Intestinal Polyposis / Diet / Cyclooxygenase 2 / Beta Catenin / Phospholipases A2 / Carcinogenesis / Inflammation Limits: Animals Language: English Journal: Journal of Cancer Prevention Year: 2015 Type: Article