Mitotic Indices and Prognosis of Advanced Bladder Cancer / 대한비뇨기과학회지

ABSTRACT

We analyzed the prognostic factors, such as sex, age, tumor shape, number, 1ocation, size, TNM stage, WHO grade, modified Bergkvist grade, treatment modality, cytology, type of progression, mitotic activity index(MAI), volume corrected mitotic index(M/V index) and pathologic grade, in a chort of 83 advanced transitional cell carcinoma of bladder who was followed for more than 3 years. N stage of TNM,WHO grade, modified Bergkvist grade and pathologic stage were related to mitotic indices(p<0.05), but cytology was related to MAI only (p<0.05).In univariate analysis of prognostic factors, sex, N and M stage of TNM, progression type, MAI & M/ V index and pathologic stage were related to 5-year survival during follow up. Multivariate analysis of prognostic factors, which were significantly related in univariate analysis, identified MAI as the most important factor(p<0.05), followed by M/V index, N stage of TNM, sex, M stage of TNM and progression type. The result show that advanced transitional cell bladder tumors can be efficiently categorized into prognostic groups by quantitative mitotic frequency analysis.