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The Combined Impact of Neutrophil-to-Lymphocyte Ratio and Type 2 Diabetic Mellitus on Significant Coronary Artery Disease and Carotid Artery Atherosclerosis
Journal of Cardiovascular Ultrasound ; : 115-122, 2016.
Article in English | WPRIM | ID: wpr-11231
ABSTRACT

BACKGROUND:

Neutrophil-to-lymphocyte ratio (NLR) has recently emerged as a new important inflammatory marker for predicting cardiovascular events. This study aimed to evaluate the combined impact of NLR and type 2 diabetes mellitus (T2DM) on significant coronary artery disease (CAD) and carotid artery atherosclerosis.

METHODS:

This study includes a total of 828 patients evaluated by coronary angiography and carotid ultrasonography. Significant CAD was defined as at least one vessel with stenosis greater than 50%. We employed logistic regression models to investigate the association of NLR and T2DM with significant CAD. The goodness-of-fit and discriminability of the models were assessed by the loglikelihood ratio test and C-index, respectively. Also, we investigated the clinical relevance of the categorized NLR that classifies patients into three risk groups (low, intermediate, high).

RESULTS:

According to logistic regression analysis, both NLR {adjusted odds ratio (OR) 1.31, p 2) showed the greater prevalence of significant CAD and carotid artery atherosclerosis compared with patients without T2DM or type 2 diabetic patients assigned into the low risk group (NLR ≤ 1).

CONCLUSION:

Our results suggest that type 2 diabetic patients with high inflammatory state would be more vulnerable to significant CAD and carotid artery atherosclerosis.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Coronary Artery Disease / Carotid Arteries / Logistic Models / Odds Ratio / Prevalence / Risk Factors / Ultrasonography / Coronary Angiography / Constriction, Pathologic / Coronary Vessels Type of study: Diagnostic study / Etiology study / Prevalence study / Prognostic study Limits: Humans Language: English Journal: Journal of Cardiovascular Ultrasound Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Coronary Artery Disease / Carotid Arteries / Logistic Models / Odds Ratio / Prevalence / Risk Factors / Ultrasonography / Coronary Angiography / Constriction, Pathologic / Coronary Vessels Type of study: Diagnostic study / Etiology study / Prevalence study / Prognostic study Limits: Humans Language: English Journal: Journal of Cardiovascular Ultrasound Year: 2016 Type: Article