Airway Obstruction after Acute Ozone Exposure in BALB/c Mice Using Barometric Plethysmography
The Korean Journal of Internal Medicine
;
: 1-5, 2003.
Article
in English
| WPRIM
| ID: wpr-112365
ABSTRACT
BACKGROUND:
Airway responsiveness after acute inhalation of ozone is related to the concentration and duration of ozone exposure. Using barometric whole-body plethysmography and increase in enhanced pause (Penh) as an index of airway obstruction, we measured the response of BALB/c mice to acute ozone inhalation to study the time course change of pulmonary function after ozone exposure.METHODS:
Penh was measured before and after exposure to filtered air or 0.12, 0.5, 1, or 2 ppm ozone for 3 hr (n=6/group). In addition, Penh was measured 24, 48 and 72 hr after ozone exposure. Bronchoalveolar lavage (BAL) and histopathologic examinations were performed.RESULTS:
The increase in Penh after ozone exposure was significantly higher in the 0.12, 0.5, 1 and 2 ppm groups compared with the control group (all p< 0.01). Increases in Penh 24 hr after ozone exposure were significantly lower than those immediately after acute ozone exposure; however, increases in Penh 72 hr after ozone exposure were significantly higher than those in the control group (each p< 0.01). The proportion of neutrophils in BAL fluid was significantly higher in the group exposed to 2 ppm ozone than in the groups exposed to filtered air or 0.12 ppm ozone (both p< 0.01).CONCLUSION:
These results indicate that airway obstruction is induced following ozone exposure in a concentration-dependent manner and persists for at least 72 hr.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plethysmography, Whole Body
/
Reference Values
/
Respiratory Function Tests
/
Sulfuric Acids
/
Bronchoalveolar Lavage Fluid
/
Probability
/
Sensitivity and Specificity
/
Statistics, Nonparametric
/
Risk Assessment
/
Airway Obstruction
Type of study:
Diagnostic study
/
Etiology study
/
Risk factors
Limits:
Animals
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2003
Type:
Article
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