Histopathologic Characteristics of Conjunctivochalasis
Journal of the Korean Ophthalmological Society
;
: 1165-1174, 2013.
Article
in Korean
| WPRIM
| ID: wpr-112416
ABSTRACT
PURPOSE:
In this study we investigated the histopathologic characteristics of conjunctivochalasis and its association with lymphangiectasis using impression cytology and conjunctival excisional biopsy in patients with conjunctivochalasis.METHODS:
This prospective study included 14 outpatients diagnosed with conjunctivochalasis, and who had excisional biopsies performed between March 1, 2012 and November 30, 2012. Preoperative slit-lamp examination, dry eye diagnostic test and impression cytology were also performed. For histological analysis, conjunctival sections were stained with hematoxylin and eosin (H&E), Verhoeff-van Gieson (VVG) elastic staining, and monoclonal antibody D2-40, a lymphatic endothelial marker.RESULTS:
Tear break-up time and Schirmer's value were decreased in patients with conjunctivochalasis. Impression cytology showed a decrease in goblet cell density and an increase in nucleoplasmic/cytoplasmic ratio. The patients' conjunctival tissues exhibited an infiltration increase of chronic inflammatory cells on H&E stain, and a decrease in collagen density with degeneration of elastic fibers on VVG stain compared to tissues from the control subjects. D2-40 immunohistochemistry revealed the dilated subconjunctival lymphatics in patients with conjunctivochalasis.CONCLUSIONS:
This study suggests that the characteristic histopathological features of conjunctivochalasis include dilated lymphatic vessels as well as decreased goblet cell and collagen densities with degeneration of elastic fibers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Outpatients
/
Biopsy
/
Immunohistochemistry
/
Prospective Studies
/
Collagen
/
Eosine Yellowish-(YS)
/
Goblet Cells
/
Lymphatic Vessels
/
Diagnostic Tests, Routine
/
Elastic Tissue
Type of study:
Observational study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2013
Type:
Article
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