Two Cases of Retinoblastoma Diagnosed by Fine needle Aspiration Biopsy

ABSTRACT

Retinoblastoma is a highly malignant intraocular tumor of childhood that requires accurate diagnosis and prompt treatment. The diagnosis of retinoblastoma is based on the fundus finding and noninvasive radiologic evaluation, but sometimes retinoblastoma is clinically misdiagnosed as nonneoplastic lesion such as Coats' disease, persistent hyperplastic primary vitreous, toxocariasis and old retinal detachment and sometimes vice versa. We performed fine needle aspiration biopsies in two cases, in whom retinoblastoma or Coats' disease was suspected but there was diagnostic uncertainty on fundus finding, orbit CT or MRI. The cytologic diagnosis of two cases was retinoblastoma. And after enucleation final histopathologic diagnosis correlated with the cytodiagnosis. We think that fine needle aspiration biopsy may be helpful in establishing the diagnosis in difficult cases of childhood leukocoria including retionblastoma.