Effects of total body irradiation-based conditioning on allogeneic stem cell transplantation for pediatric acute leukemia: a single-institution study
Radiation Oncology Journal
;
: 198-207, 2014.
Article
in English
| WPRIM
| ID: wpr-112698
ABSTRACT
PURPOSE:
To evaluate the effects of total body irradiation (TBI), as a conditioning regimen prior to allogeneic stem cell transplantation (allo-SCT), in pediatric acute leukemia patients. MATERIALS ANDMETHODS:
From January 2001 to December 2011, 28 patients, aged less than 18 years, were treated with TBI-based conditioning for allo-SCT in our institution. Of the 28 patients, 21 patients were diagnosed with acute lymphoblastic leukemia (ALL, 75%) and 7 were diagnosed with acute myeloid leukemia (AML, 25%). TBI was completed 4 days or 1 day before stem cell infusion. Patients underwent radiation therapy with bilateral parallel opposing fields and 6-MV X-rays. The Kaplan-Meier method was used to calculate survival outcomes.RESULTS:
The 2-year event-free survival and overall survival rates were 66% and 56%, respectively (71.4% and 60.0% in AML patients vs. 64.3% and 52.4% in ALL patients, respectively). Treatment related mortality rate were 25%. Acute and chronic graft-versus-host disease was a major complication; other complications included endocrine dysfunction and pulmonary complications. Common complications from TBI were nausea (89%) and cataracts (7.1%).CONCLUSION:
The efficacy and toxicity data in this study of TBI-based conditioning to pediatric acute leukemia patients were comparable with previous studies. However, clinicians need to focus on the acute and chronic complications related to allo-SCT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stem Cells
/
Cataract
/
Leukemia, Myeloid, Acute
/
Leukemia
/
Survival Rate
/
Mortality
/
Whole-Body Irradiation
/
Disease-Free Survival
/
Stem Cell Transplantation
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Type of study:
Prognostic study
Limits:
Child
/
Humans
Language:
English
Journal:
Radiation Oncology Journal
Year:
2014
Type:
Article
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