cGAS-cGAMP Signaling and Antiviral Defense
Journal of Bacteriology and Virology
;
: 112-114, 2014.
Article
in English
| WPRIM
| ID: wpr-112738
ABSTRACT
Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that plays an important role in innate immunity. Transfection of DNA or DNA virus infection results in the induction of type I interferon production in fibroblasts, macrophages, and dendritic cells which is dependent on cGAS. Recently, cGas (-/-) mice have been reported to be more vulnerable to fatal infection with herpes simplex virus 1 (HSV1) as compared to wild-type mice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Dendritic Cells
/
DNA
/
Transfection
/
Interferon Type I
/
Herpesvirus 1, Human
/
Cytosol
/
DNA Virus Infections
/
Fibroblasts
/
Guanosine
/
Immunity, Innate
Limits:
Animals
Language:
English
Journal:
Journal of Bacteriology and Virology
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS