The Skeletal Site-Differential Changes in Bone Mineral Density Following Bone Marrow Transplantation: 3-Year Prospective Study
Journal of Korean Medical Science
;
: 749-754, 2002.
Article
in English
| WPRIM
| ID: wpr-112883
ABSTRACT
Loss of bone mass is usually detected after bone marrow transplantation (BMT) during the early post-transplant period. However, little is known about the long-term effects of BMT on bone metabolism. We have prospectively investigated 11 patients undergoing BMT. Bone mineral density (BMD) was measured before BMT, and 1, 2, and 3 yr after BMT. Serum markers of bone turnover were serially measured before BMT and 1, 2, 3, 4, and 12 weeks, 6 months, and 1 yr after BMT. The mean change in the lumbar spine (L2-4) BMD, calculated as the percent change from the baseline to the level at 1, 2, and 3 yr was -4.7% (NS), -1.1% (NS), and +6.4% (p<0.05), respectively. The mean change in the total proximal femur BMD from the baseline to the level at 1, 2, and 3 yr was -8.5% (p<0.01), -8.7% (p<0.05) and -5.6% (p<0.05), respectively. In summary, there was little decline in lumbar BMD at 1 yr following BMT and gradual recovery until 3 yr. In contrast, femoral BMD decreased much more than the lumbar area at 1 yr and did not recover until 3 yr. The mechanism of skeletal site-selective differences in the changes of BMD needs to be elucidated.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptides
/
Time Factors
/
Bone and Bones
/
Myelodysplastic Syndromes
/
Luteinizing Hormone
/
Leukemia
/
Bone Density
/
Prospective Studies
/
Collagen
/
Bone Marrow Transplantation
Type of study:
Observational study
Limits:
Adult
/
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2002
Type:
Article
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