In vitro Activity of Gemifloxacin Against Recent Clinical Isolates of Bacteria in Korea
Journal of Korean Medical Science
;
: 737-742, 2002.
Article
in English
| WPRIM
| ID: wpr-112885
ABSTRACT
Gemifloxacin is an enhanced-affinity fluoroquinolone with broad-spectrum antibacterial activity. In Korea, resistant bacteria are relatively more prevalent than in other industrialized countries. In this study, we studied the in vitro activities of gemifloxacin, gatifloxacin, moxifloxacin, levofloxacin, ciprofloxacin, and other commonly used antimicrobial agents against 1,689 bacterial strains isolated at four Korean university hospitals during 1999-2000. Minimum inhibitory concentrations (MICs) were determined using the agar dilution method of National Committee for Clinical Laboratory Standards. Gemifloxacin had the lowest MICs for the respiratory pathogens 90% of Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae were inhibited by 0.06, 0.03, and 0.03 mg/L, respectively. Gemifloxacin was more active than the other fluoroquinolones against methicillin-susceptible Staphylococcus aureus, coagulase-negative staphylococci, streptococci, and Enterococcus faecalis. The MIC90s of gemifloxacin for Klebsiella oxytoca, Proteus vulgaris, and nontyphoidal Salmonella spp. were 0.25, 1.0, and 0.12 mg/L, respectively, while those for other Gram-negative bacilli were 4-64 mg/L. In conclusion, gemifloxacin was the most active among the comparative agents against Gram-positive species, including respiratory pathogens isolated in Korea.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quinolines
/
Streptococcus pneumoniae
/
Aza Compounds
/
Bacteria
/
Ofloxacin
/
Ciprofloxacin
/
Microbial Sensitivity Tests
/
Haemophilus influenzae
/
Fluoroquinolones
/
Korea
Type of study:
Practice guideline
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2002
Type:
Article
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