Comparison of plasma lipid and lipoprotein concentrations in normal and intrauterine growth restriction pregnancies / 대한산부인과학회지

ABSTRACT

OBJECTIVE: The effects of fetal growth of lipid metabolism in pregnancy are not well understood at present. The aim of this study was to perform a cross sectional study of lipid and lipidprotein concentrations in the 3rd trimester, from normal pregnancies and those complicated by intrauterine growth restriction pregnancies (IUGR) without preeclampsia. METHODS: Fasting blood samples for lipid and lipidprotein fractions were taken 3rd trimester. from fourty two women with IUGR; fourty five women with uncomplicated pregnancies matched as a group for age, parity, gestational age and fetal body weight. RESULTS: Total cholesterol (6.74+/-1.14 mmol/L vs 4.23+/-1.03 mmol/L, P<0.01), triglyceride 2.10+/-0.95 mmol/L vs 2.42+/-0.73 mmol/L. P<0.05) and LDL (3.41+/-0.83 mmol/L vs 4.23+/-1.07 mmol/L, P<0.01) concentrations were significantly lower in the IUGR group than in normal group. Free fatty acid (0.8+/-0.21 mmol/L vs 0.5+/-0.01 mmol/L, P<0.01) concentration, ApoB/ApoA ratio (0.86+/-0.42 vs 0.77+/-0.47, P<0.01). HDL/ApoA (0.87+/-0.1 vs 0.72+/-0.05, P<0.05) ratio were significantly higher in the IUGR group than in normal group. There were no difference in other lipids. CONCLUSION: The results of this study suggest that LDL levels, which normally increase in uncomplicated pregnancies, fail to rise appropriately in pregnancies complicated by IUGR and may play a role in the pathogenesis of fetal growth restriction. Change in ApoA and increased ApoB/ApoA ratio may be used in identifying mothers with, or at risk of, a pregnancy complicated by IUGR.