Non-typhoidal Salmonella Gastroenteritis in Childhood: Clinical Features and Antibiotics Resistance / 대한소아소화기영양학회지
Korean Journal of Pediatric Gastroenterology and Nutrition
;
: 150-157, 2002.
Article
in Korean
| WPRIM
| ID: wpr-112963
ABSTRACT
PURPOSE:
As the incidence of non-typhoidal salmonella strains resistant to antibiotics has been increased, we attempted to investigate clinical aspects of non-typhoidal salmonella gastroenteritis and antibiotics resistance.METHODS:
From January 2000 to June 2002, 99 children with positive stool culture of non-typhoidal salmonella were studied about clinical features, the incidence of antibiotics and multi-drug resistance and the difference of incidence of antibiotics resistance according to immune status.RESULTS:
There were 66 males and 33 females. The majority of them were under 5 years of age (71%). 25 children were immunocompromised due to chemotherapy, steroid or immunosuppressive treatment. Serogroup D was the most common isolates (65%) followed by B (16%), C (8%) and E (8%). Resistance rate of 30% to ampicillin, 12% to chloramphenicol, 20% to trimethoprim- sulfamethoxazole (TMP-SMX), 11% to cefotaxime and 8% to cefixime were obtained. All isolates were susceptible to ciprofloxacine. Resistance rate to cefotaxime and cefixime in immunocompromised patients was 24% and 14.3% respectively, which were significantly higher compared to that in immunocompetent patients (6.8%, 5.6%, p<0.05). 11 isolates were resistant to three or more antibiotics. The incidence of multi-drug resistant isolates was significantly higher in immunocompromised patients (24%) than that of immunocompetent patients (6.8%).CONCLUSION:
Because of the high prevalence of non-typhoidal salmonella strains resistant to ampicillin, chloramphenicol and TMP-SMX, third-generation cephalosporin might be the treatment of choice in non-typhoidal salmonella gastroenteritis. In particular, antibiotics should be carefully selected in immunocompromised patients because non-typhoidal salmonellas from them showed the higher incidence of antibiotic resistance and multi-drug resistance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Salmonella
/
Sulfamethoxazole
/
Drug Resistance, Microbial
/
Ciprofloxacin
/
Cefotaxime
/
Trimethoprim, Sulfamethoxazole Drug Combination
/
Chloramphenicol
/
Incidence
/
Prevalence
/
Immunocompromised Host
Type of study:
Incidence study
/
Prevalence study
/
Prognostic study
Limits:
Child
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Pediatric Gastroenterology and Nutrition
Year:
2002
Type:
Article
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