Placental Apoptosis in Preeclampsia / 대한주산의학회잡지
Korean Journal of Perinatology
;
: 267-273, 2002.
Article
in Korean
| WPRIM
| ID: wpr-112973
ABSTRACT
OBJECTIVE:
To investigate the change of placental apoptosis and the expression of their mediator in preeclampsia women.METHODS:
Placental tissues from 10 cases of preeclampsia and 15 cases of normal pregnancy were analyzed using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling(TUNEL) staining. Expressions of bcl-2, bax, caspase-3 was also assessed using immunohistochemistry.RESULTS:
In TUNEL staining, the number of apoptotic nuclei were significantly increased in the trophoblast of preeclampsia than normal pregnancy. Bcl-2 was mainly expressed in syncytiotrophoblast and bax was mainly expressed in cytotrophoblast. Bcl-2 expression was decreased and bax expression was increased in the preeclampsia than normal, but the difference was not significant. Caspase-3 was mainly expressed in the cytotrophoblast and expression was significantly increased in the preeclampsia than normal pregnancy(p<0.05).CONCLUSION:
Placental apoptosis, especially accompanied with increased expression of caspase-3 in cytotrophoblast, might be related with in the pathogenesis of preeclampsia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Placenta
/
Pre-Eclampsia
/
Trophoblasts
/
Immunohistochemistry
/
Apoptosis
/
In Situ Nick-End Labeling
/
Deoxyuridine
/
Caspase 3
Limits:
Female
/
Humans
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Perinatology
Year:
2002
Type:
Article
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