A Clinical and Histopathologic Study of Thirteen Cases of Phenytoin Induced Drug Eruption / 대한피부과학회지
Korean Journal of Dermatology
;
: 599-605, 1987.
Article
in Korean
| WPRIM
| ID: wpr-113309
ABSTRACT
The study comprises 13 cases of phenytoin induced drug eruption admitted and treated at Seoul National University Hospital during a 6-year period (1981-1986). The summaries are as follows 1. The skin lesions were usually pruritic morbilliform maculopapular eruptions on face, trunk, extremites, including palms and soles. However, erythema multiform was observed in one case. 2. Hiistopathologically, the dermis showed perivascular accumulation of mononuclear cells with occasional eosinophils. In some cases, the epidermis showed vacuolar alteration of basaI layer, necrotic keratinocyte with dermal perivascular mononuclear cell infiltrations. 3. The frequencies of the associated features were as follows fever(61.5%), lymphadenopathy(23.1%), leukocytosis(45.5%), esinophilia(72.7%), and liver function abnormalities(63.6%)
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenytoin
/
Skin
/
Keratinocytes
/
Drug Eruptions
/
Dermis
/
Eosinophils
/
Epidermis
/
Erythema
/
Seoul
/
Liver
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
1987
Type:
Article
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