Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors
Journal of Veterinary Science
;
: 1-7, 2009.
Article
in English
| WPRIM
| ID: wpr-113694
ABSTRACT
Primary testicular tumors are the most common causes of cancer in male dogs. Overall, the majority of canine patients should be cured by testicular surgery. However, tumor markers are not well-known in veterinary medicine. We sought to determine using immunohistochemistry whether the combined human testicular tumor markers (placental alkaline phosphatase, OCT3/4, CD30, alpha-fetoprotein, inhibin-alpha, vimentin, c-KIT, and desmin) are expressed in canine seminomas and Sertoli cell tumors (SCTs). We examined 35 canine testicular tumors, 20 seminomas and 15 SCTs. c-KIT was expressed markedly in canine seminomas. Both inhibin-alpha and vimentin were expressed significantly in canine SCTs. The results of this study demonstrate differences and similarities between tumor marker expression of testicular tumors in dogs and humans. All the main markers in current routine use are discussed as well as potential useful markers for benign and malignant tumors, and tumor progression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sertoli Cell Tumor
/
Immunohistochemistry
/
Biomarkers, Tumor
/
Seminoma
/
Dog Diseases
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2009
Type:
Article
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