The Effect of Acetylcholine Esterase Inhibitor on Cerebrospinal Fluid beta-Amyloid 1-42 and Phosphorylated Tau Protein in Korean Alzheimer's Disease Patients: Preliminary Study
Journal of the Korean Neurological Association
;
: 224-230, 2008.
Article
in Korean
| WPRIM
| ID: wpr-113740
ABSTRACT
BACKGROUND:
Alzheimer's disease (AD) is characterized by the pathology of amyloid plaques and tau-associated neurofibrillary tangles. Acetylcholine esterase (AChE) transforms the beta-amyloid monomer into an oligomer, and increases beta-amyloid aggregation in the brain. Increased beta-amyloid breaks the cytoskeleton of the brain by hyperphosphorylation of the tau protein. Previous studies support that AChE inhibitor has an inhibitory effect on toxicity of the beta-amyloid and phophorylated tau protein. The purpose of this study was to analyze the CSF beta-amyloid 1-42 (A beta 1-42) and phosphorylated tau protein in AD and determine their difference depending on whether AChE inhibitor was taken or not.METHODS:
Subjects included 16 AD, 14 normal controls, and 15 disease controls. Nine of AD group had taken an AChE inhibitor while the remainder had not. The CSF A beta 1-42 and phosphorylated tau were measured by ELISA.RESULTS:
The CSF A beta 1-42 levels were lower in AD patients than in other groups (p<0.01). We also found increased CSF A beta 1-42 levels in the AChE inhibitor users, compared with non-users.CONCLUSIONS:
The level of CSF A beta 1-42 may have a diagnostic value in the patients with cognitive impairments. Also, we may expect the effect of AChE inhibitor on Alzheimer's pathology by measuring CSF A beta 1-42 levels. Therefore, the level of CSF A beta 1-42 may serve as a biological surrogate marker for AD treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cytoskeleton
/
Brain
/
Biomarkers
/
Acetylcholine
/
Neurofibrillary Tangles
/
Tau Proteins
/
Plaque, Amyloid
/
Alzheimer Disease
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
2008
Type:
Article
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