Nitric Oxide Synthesis in the Adult and Developing Kidney
Electrolytes & Blood Pressure
;
: 1-7, 2006.
Article
in English
| WPRIM
| ID: wpr-114004
ABSTRACT
Nitric oxide (NO) is synthesized within the adult and developing kidney and plays a critical role in the regulation of renal hemodynamics and tubule function. In the adult kidney, the regulation of NO synthesis is very cell type specific and subject to distinct control mechanisms of NO synthase (NOS) isoforms. Endothelial NOS (eNOS) is expressed in the endothelial cells of glomeruli, peritubular capillaries, and vascular bundles. Neuronal NOS (nNOS) is expressed in the tubular epithelial cells of the macula densa and inner medullary collecting duct. Furthermore, in the immature kidney, the expression of eNOS and nNOS shows unique patterns distinct from that is observed in the adult. This review will summarize the localization and presumable function of NOS isoforms in the adult and developing kidney.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Capillaries
/
Nitric Oxide Synthase
/
Protein Isoforms
/
Endothelial Cells
/
Epithelial Cells
/
Hemodynamics
/
Kidney
/
Neurons
/
Nitric Oxide
Limits:
Adult
/
Humans
Language:
English
Journal:
Electrolytes & Blood Pressure
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS