Association of Prostate Specific Antigen (PSA) Velocity with Age and Initial PSA in Healthy Korean Men / 대한남성과학회지
Korean Journal of Andrology
;
: 16-21, 2010.
Article
in English
| WPRIM
| ID: wpr-11406
ABSTRACT
PURPOSE:
Prostate specific antigen (PSA) is a test with relatively low specificity used for determination of risk for prostate cancer. PSA velocity (PSAV) has been used as a complimentary test. We investigated the association of PSAV with age and an initial PSA. MATERIALS ANDMETHODS:
We enrolled 989 healthy men with initial PSA of 4.0ng/ml or lower. The PSA levels were measured at intervals of at least 12 months. We analyzed the influence of age and initial PSA on the PSAV.RESULTS:
PSAV was directly correlated with age and the initial PSA. The initial PSA was not correlated with the PSAV when adjusted by age (r=0.009, p=0.773); age was correlated with PSAV when adjusted by initial PSA level (r=0.276, p<0.001). The mean PSAV in cases with initial PSA of 2.1-4.0 ng/ml was significantly greater compared to the cases with an initial PSA of 0-2.0 ng/ml (p<0.01). The ratio of the men with a PSAV greater than 0.75 ng/ml/year was significantly higher in cases with an initial PSA of 2.1-4.0 ng/ml (p<0.05).CONCLUSIONS:
PSAV is associated with age and an initial PSA level in healthy Korean men. Men with initial PSA of 2.1-4.0 ng/ml had an abnormal PSAV in high proportion, and therefore annual follow up PSA would be useful for the early detection of prostate cancer in these cases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Prostatic Neoplasms
/
Follow-Up Studies
/
Sensitivity and Specificity
/
Prostate-Specific Antigen
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Screening study
Limits:
Humans
/
Male
Language:
English
Journal:
Korean Journal of Andrology
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS