Effects of propofol on beta-adrenoceptor-mediated signal transduction in cardiac muscle; role of cAMP / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 374-377, 2010.
Article
in English
| WPRIM
| ID: wpr-11416
ABSTRACT
BACKGROUND:
Propofol may decrease myocardial contractility via actions on the beta-adrenoceptor-mediated signal transduction. The aim of this study was to evaluate the effect of propofol via beta-adrenoceptor-mediated signal transduction by measuring the tissue levels of cAMP (cyclic adenosine monophosphate).METHODS:
The effects of propofol on beta-adrenoceptor mediated cascades were measured with cAMP concentrations, which were stimulated by agonists (l-isoproterenol, GTPgammaS, and forskolin) of each step of beta-adrenoceptor-mediated cascades.RESULTS:
While the production of cAMP stimulated by isoproterenol, GTPgammaS, or forskolin are increased (P < 0.05), application of each concentration of propofol (0.1, 1, 10, 100 micrometer) did not alter the levels of cAMP.CONCLUSIONS:
Considering that propofol did not alter the tissue cAMP levels when stimulated by isoproterenol, GTPgammaS, and forskolin, propofol appears to have no effect on the beta-adrenoceptor signaling pathway in guinea pig ventricular myocardium.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Colforsin
/
Signal Transduction
/
Propofol
/
Adenosine
/
Guanosine 5'-O-(3-Thiotriphosphate)
/
GTP-Binding Proteins
/
Guinea Pigs
/
Isoproterenol
/
Myocardium
Limits:
Animals
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2010
Type:
Article
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