Effect of Parathyroid Hormone on Left Ventricular Hypertrophy in Aged Ovariectomized Rats
Korean Circulation Journal
;
: 953-960, 1998.
Article
in Korean
| WPRIM
| ID: wpr-114163
ABSTRACT
BACKGROUND:
It has been well known that the bone and kidney are the principle organs of parathyroid hormine (PTH) actions. Although patients with primary hyperparathyroidism show a high incidence of LVH and trophic effects of PTH on adult rat ventricular cardiomyocytes were investigated in vitro, effect of PTH on the cardiac tissue in vivo is unknown.METHODS:
We examined the effects of PTH on the cardiomyocyte and interstitial tissue using adult rat heart. Twenty-two female Sprague-Dawley rats were ovariectomized bilaterally at three months old and weighing in 250 - 300 gm in order to exclude the trophic effect of estrogen. We administrated human parathyroid hormone (20 ug subcutaneously 5 times per week) to 12 rats for 4 weeks after raising for 8 weeks (PTH group)the remaining 10 rats received only normal saline (control). We measured left ventricular thickness [IVS+LVPW)/2] and number of cardiomyocytes and interstitial fibrosis on LM (H & E and Masson's trochrome stain) and EM.RESULTS:
1) LV wall thickeness tended to increase in PTH group as compared with control (2.16+/-0.31 vs 1.12+/-0.21 mm, p=0.099). 2) The number of cardiomyocyte in PTH group was significantly less than that of control (61.2+/-13.1 vs 70.5+/-14.9, p=0.003, Magnification x 400). 3) There was no significant change of interstitial fibrosis between PTH group and control.CONCLUSION:
These results shggest that PTH may produce left ventricular hypertrophic effects in aged ovariectomized rat that resulted form hypertrophy of cardiomyocyte without increase of interstitial connetive tissue.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parathyroid Hormone
/
Fibrosis
/
Ovariectomy
/
Incidence
/
Rats, Sprague-Dawley
/
Hypertrophy, Left Ventricular
/
Myocytes, Cardiac
/
Hyperparathyroidism, Primary
/
Estrogens
/
Heart
Type of study:
Incidence study
/
Prognostic study
Limits:
Animals
/
Female
/
Humans
Language:
Korean
Journal:
Korean Circulation Journal
Year:
1998
Type:
Article
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