Association of SNAP-25 Gene Ddel and Mnll Polymorphisms with Adult Attention Deficit Hyperactivity Disorder
Psychiatry Investigation
;
: 476-480, 2014.
Article
in English
| WPRIM
| ID: wpr-114484
ABSTRACT
OBJECTIVE:
The synaptosomal-associated protein of 25 kDa (SNAP-25) gene is a presynaptic plasma membrane protein and an integral component of the vesicle docking and fusion machinery mediating secretion of neurotransmitters. Previously, several studies reported association between SNAP-25 and attention deficit hyperactivity disorder (ADHD). We investigated whether these SNAP-25 polymorphisms (MnlI T/G and DdelI T/C) were also associated with ADHD in the Turkish population.METHODS:
Our study comprised unrelated 139 subjects who met DSM-IV criteria for ADHD and 73 controls and all were of Turkish origin. Genetic analyses were performed and patients were evaluated with Wender-Utah Rating Scale and Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale.RESULTS:
SNAP-25 DdelI polymorphism was not associated with ADHD but there was a statistically significant difference between ADHD patients and controls for SNAP-25 MnlI polymorphism. For SNAP-25 MnlI polymorphism patients with G/G genotype of the SNAP-25 gene MnlI polymorphism had higher Wender-Utah scores and higher scores in the 1st and 3rd parts of adult ADD/ADHD Scale.CONCLUSION:
We detected a significant association of the MnlI polymorphism in our ADHD sample which was similar to previous findings. Our study also revealed that SNAP-25 MnlI polymorphism was also associated with symptom severity of ADHD. This study is also, the first report on the association of SNAP-25 with ADHD in the Turkish population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Attention Deficit Disorder with Hyperactivity
/
Cell Membrane
/
Mass Screening
/
Negotiating
/
Neurotransmitter Agents
/
Diagnostic and Statistical Manual of Mental Disorders
/
Genotype
Type of study:
Prognostic study
/
Screening study
Limits:
Adult
/
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2014
Type:
Article
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