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Novel Surgical Technique for Orthotopic Testicular Transplantation in Rats / 대한남성과학회지
Korean Journal of Andrology ; : 88-93, 2005.
Article in Korean | WPRIM | ID: wpr-114513
ABSTRACT

PURPOSE:

This study was performed to evaluate the functional and histological changes following orthotopic testicular transplantation. A new microsurgical technique was used for the transplantation. MATERIALS AND

METHODS:

Recipient rats were castrated, and microsurgically-removed testes from adult rats were utilized for orthotopic transplantation. Animals were divided into three groups(1) the control group(n=6);(2) the castrated group(n=6);(3) the orthotopic testis transplantation group (n=12). In order to identify the survival of the testis after transplantation, testicular scans and histopathological examinations were performed.

RESULTS:

The following results were obtained from examination of transplanted testes 1. Histopathologic findings. Excluding 2 transplanted rats which demonstrated ischemic necrosis, the testes of the other 10 transplantated rats showed almost normal histologic findings. 2. Testicular scan. Testicular scan was effective to differentiate the successfully transplanted testes from the testes with ischemic necrosis.

CONCLUSIONS:

These results demonstrate that orthotopic transplantation has a higher possibility of graft survival, and testicular scan is aneffective method to confirm the survival of transplanted testes. In addition, newly-developed orthotopic transplantation animal models could be used for research on the hypothalamus-pituitary-testis axis. The orthotopic transplantation technique could alsobe used as a new therapeutic method for congenital and acquired hypogonadism patients.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Axis, Cervical Vertebra / Testis / Models, Animal / Graft Survival / Hypogonadism / Necrosis Type of study: Prognostic study Limits: Animals / Humans Language: Korean Journal: Korean Journal of Andrology Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Axis, Cervical Vertebra / Testis / Models, Animal / Graft Survival / Hypogonadism / Necrosis Type of study: Prognostic study Limits: Animals / Humans Language: Korean Journal: Korean Journal of Andrology Year: 2005 Type: Article