GnRH antagonist multiple dose protocol with oral contraceptive pill pretreatment in poor responders undergoing IVF/ICSI / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
;
: 228-233, 2011.
Article
in English
| WPRIM
| ID: wpr-11473
ABSTRACT
OBJECTIVE:
To investigate the effectiveness of GnRH antagonist multiple-dose protocol (MDP) with oral contraceptive pill (OCP) pretreatment in poor responders undergoing IVF/ICSI, compared with GnRH antagonist MDP without OCP pretreatment and GnRH agonist low-dose long protocol (LP).METHODS:
A total of 120 poor responders were randomized into three groups according to controlled ovarian stimulation (COS) options; GnRH antagonist MDP after OCP pretreatment (group 1), GnRH antagonist MDP without OCP pretreatment (group 2) or GnRH agonist luteal low-dose LP without OCP pretreatment (group 3). Patients allocated in group 1 were pretreated with OCP for 21days in the cycle preceding COS, and ovarian stimulation using recombinant human FSH (rhFSH) was started 5 days after discontinuation of OCP.RESULTS:
There were no differences in patients' characteristics among three groups. Total dose and days of rhFSH used for COS were significantly higher in group 3 than in group 1 or 2. The numbers of mature oocytes, fertilized oocytes and grade I, II embryos were significantly lower in group 2 than in group 1 or 3. There were no significant differences in the clinical pregnancy rate and implantation rate among three groups.CONCLUSION:
GnRH antagonist MDP with OCP pretreatment is at least as effective as GnRH agonist low-dose LP in poor responders and can benefit the poor responders by reducing the amount and duration of FSH required for follicular maturation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oocytes
/
Ovulation Induction
/
Fertilization in Vitro
/
Gonadotropin-Releasing Hormone
/
Pregnancy Rate
/
Contraceptives, Oral
/
Sperm Injections, Intracytoplasmic
/
Follicle Stimulating Hormone, Human
/
Embryonic Structures
Type of study:
Controlled clinical trial
/
Practice guideline
Limits:
Humans
Language:
English
Journal:
Clinical and Experimental Reproductive Medicine
Year:
2011
Type:
Article
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