Effect of a Long-term, Oral Fixed Dose with a Combination of Aledronate and Cacitriol on the Cancellous Bone Microarchitecture in Ovariectomized Rats / 대한정형외과연구학회지
Journal of Korean Orthopaedic Research Society
;
: 24-32, 2011.
Article
in English
| WPRIM
| ID: wpr-114888
ABSTRACT
PURPOSE:
To study the effect of a long-term, oral, fixed dose with a combination of alendronate and calcitriol on the cancellous bone microarchitecture in an ovariectomized rat model. MATERIALS ANDMETHODS:
Twenty eight female Sprague-Dawley rats were divided into 2 equal groups a non-medication group (OVX), and a medication group (ALD). The ALD group was treated with an oral daily fixed dose with a combination of alendronate and calcitriol for six months, starting from 4 weeks after ovariectomy, while the OVX group was given only a placebo. After six months, all animals were sacrificed, and an in vitro micro-CT analysis of the the distal femur was performed. The bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), trabecular number (Tb.N), structure model index (SMI), connectivity density (Conn.D), and bone mineral density (BMD) were assessed.RESULTS:
The ALD group had significantly higher BV/TV, Tb N, BMD and Conn.D and it also had significantly lower Tb Sp and SMI than the OVX group.CONCLUSION:
A long term, daily, oral fixed dose with a combination of alendronate and calcitriol could significantly reduce the osteoporotic changes in this ovariectomized rat model.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Calcitriol
/
Ovariectomy
/
Bone Density
/
Rats, Sprague-Dawley
/
Alendronate
/
Femur
Type of study:
Controlled clinical trial
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Journal of Korean Orthopaedic Research Society
Year:
2011
Type:
Article
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