A Case of Delayed Severe Hypersensitivity Reaction during Genexol-PM(R) Infusion / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 294-297, 2010.
Article
in Korean
| WPRIM
| ID: wpr-114968
ABSTRACT
Although Taxol(R) is one of the most successful drugs in current cancer chemotherapy against solid tumors, a major problem is hypersensitivity reactions that arises as a consequence of activation of the complement (C) system, "C activation-related pseudo-allergy". Most severe hypersenstivity reactions occur within the first few minutes of Taxol(R) administration, usually after the first or second dose. Here we report a case of a severe hypersensitivity reaction in a 72-year-old man undergoing Genexol-PM(R) infusion. Hypotension and polymorphic pruritic skin rash appeared 2 hours after the start of Genexol-PM(R) infusion (with an appropriate premedication). Treating with methylprednisolone, epinephrine and inotropic agents, reduced the hypotension and the skin rash disappeared. We report this case with a review of the literature.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Purpura
/
Complement System Proteins
/
Methylprednisolone
/
Epinephrine
/
Paclitaxel
/
Exanthema
/
Hypersensitivity
/
Hypersensitivity, Delayed
/
Hypotension
/
Anaphylaxis
Limits:
Aged
/
Humans
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2010
Type:
Article
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