Prognosis of Invasive Pulmonary Aspergillosis in Patients with Hematologic Diseases in Korea / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 284-292, 2012.
Article
in English
| WPRIM
| ID: wpr-114986
ABSTRACT
BACKGROUND:
The aim of this study was to investigate therapeutic outcomes and assess factors associated with therapeutic outcomes in hematologic patients with invasive pulmonary aspergillosis (IPA).METHODS:
We analyzed all consecutive cases of IPA in adults with hematologic diseases from January 2008 to January 2009 at a Catholic Hematopoietic Stem Cell Transplantation (HSCT) Center in Seoul, Korea.RESULTS:
A total of 54 patients were identified. Underlying diseases were acute myelogenous leukemia (n=25), acute lymphoblastic leukemia (n=10), myelodysplastic syndrome (n=7), chronic myelogenous leukemia (n=3), multiple myeloma (n=3), severe aplastic anemia (n=2) and other hematologic diseases (n=4). Twenty six patients (48.2%) were assessed as having a favorable response, of which 16 patients (29.6%) showed complete response. Overall 12-week mortality and IPA attributable mortality were 38.9% (n=21) and 33.3% (n=18), respectively. In multivariate analysis, uncontrolled underlying disease (odds ratio [OR], 7.31; 95% confidence interval [CI], 1.49~35.94; p=0.014) was associated with an unfavorable response, and for 12-week mortality, uncontrolled underlying disease (OR, 11.79; 95% CI, 1.49~93.46; p=0.020) and hypoalbuminemia (OR, 9.89; 95% CI, 1.42~68.99; p=0.021) were significantly poor prognostic factors.CONCLUSION:
IPA still remains as a poor therapeutic outcome, especially in patients with refractory hematologic diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Myelodysplastic Syndromes
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Leukemia, Myeloid, Acute
/
Multivariate Analysis
/
Hematopoietic Stem Cell Transplantation
/
Hypoalbuminemia
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Invasive Pulmonary Aspergillosis
/
Hematologic Diseases
Type of study:
Prognostic study
Limits:
Adult
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Tuberculosis and Respiratory Diseases
Year:
2012
Type:
Article
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