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Clinical significance of radiotherapy in patients with primary uterine carcinosarcoma: a multicenter retrospective study (KROG 13-08) / 부인종양
Journal of Gynecologic Oncology ; : e58-2016.
Article in English | WPRIM | ID: wpr-115240
ABSTRACT

OBJECTIVE:

To investigate the role of radiotherapy (RT) in patients who underwent hysterectomy for uterine carcinosarcoma (UCS).

METHODS:

Patients with the International Federation of Gynecology and Obstetrics stage I–IVa UCS who were treated between 1990 and 2012 were identified retrospectively in a multi-institutional database. Of 235 identified patients, 97 (41.3%) received adjuvant RT. Twenty-two patients with a history of previous pelvic RT were analyzed separately. Survival outcomes were assessed using the Kaplan-Meier method and Cox proportional hazards model.

RESULTS:

Patients with a previous history of pelvic RT had poor survival outcomes, and 72.6% of these patients experienced locoregional recurrence; however, none received RT after a diagnosis of UCS. Univariate analyses revealed that pelvic lymphadenectomy (PLND) and para-aortic lymph node sampling were significant factors for locoregional recurrence-free survival (LRRFS) and disease-free survival (DFS). Among patients without previous pelvic RT, the percentage of locoregional failure was lower for those who received adjuvant RT than for those who did not (28.5% vs. 17.5%, p=0.107). Multivariate analysis revealed significant correlations between PLND and LRRFS, distant metastasis-free survival, and DFS. In subgroup analyses, RT significantly improved the 5-year LRRFS rate of patients who did not undergo PLND (52.7% vs. 18.7% for non-RT, p<0.001).

CONCLUSION:

Adjuvant RT decreased the risk of locoregional recurrence after hysterectomy for UCS, particularly in patients without surgical nodal staging. Given the poorer locoregional outcomes of patients previously subjected to pelvic RT, meticulous re-administration of RT might improve locoregional control while leading to less toxicity in these patients.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Uterine Neoplasms / Carcinosarcoma / Proportional Hazards Models / Survival Rate / Retrospective Studies / Chemotherapy, Adjuvant / Radiotherapy, Adjuvant / Kaplan-Meier Estimate / Hysterectomy / Lymph Node Excision Type of study: Observational study / Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans Language: English Journal: Journal of Gynecologic Oncology Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Uterine Neoplasms / Carcinosarcoma / Proportional Hazards Models / Survival Rate / Retrospective Studies / Chemotherapy, Adjuvant / Radiotherapy, Adjuvant / Kaplan-Meier Estimate / Hysterectomy / Lymph Node Excision Type of study: Observational study / Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans Language: English Journal: Journal of Gynecologic Oncology Year: 2016 Type: Article