Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin

Seok-Joon LEE; Sang-Tae OH; Gab-Man PARK; Tong-Soo KIM; Jae-Sook RYU; Han-Kyu CHOI; Seok-Joon LEE; Sang-Tae OH; Gab-Man PARK; Tong-Soo KIM; Jae-Sook RYU; Han-Kyu CHOI

Seok-Joon LEE; Sang-Tae OH; Gab-Man PARK; Tong-Soo KIM; Jae-Sook RYU; Han-Kyu CHOI; Seok-Joon LEE; Sang-Tae OH; Gab-Man PARK; Tong-Soo KIM; Jae-Sook RYU; Han-Kyu CHOI.

The Korean Journal of Parasitology ; : 123-126, 2005.

Article in English | WPRIM | ID: wpr-115349

ABSTRACT

ABSTRACT

Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10 beta-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin.

Subject(s)

Animals; Antimalarials/chemistry; Artemisinins/chemistry; Chloroquine/pharmacology; Drug Resistance; Plasmodium falciparum/drug effects

Plasmodium falciparum; antimalarial activity; artemisinin; dihydroartemisinin; synthesis; natural product

Fulltext

XML

Search on Google

Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasmodium falciparum / Drug Resistance / Chloroquine / Artemisinins / Antimalarials Limits: Animals Language: English Journal: The Korean Journal of Parasitology Year: 2005 Type: Article

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

Search on Google