Risk Factors for the Early Recognition of Cow's Milk Protein-induced Enterocolitis / 소아과
Korean Journal of Pediatrics
;
: 991-997, 2005.
Article
in Korean
| WPRIM
| ID: wpr-115360
ABSTRACT
PURPOSE:
Cow's milk protein-induced enterocolitis (CMPIE) is a symptom complex of vomiting and/ or diarrhea caused by delayed hypersensitivity and may result in serious complications. This study was undertaken to identify high risk factors to facilitate the early recognition of CMPIE.METHODS:
We reviewed the data of 101 patients, aged 15 to 45 days, admitted due to vomiting and/ or diarrhea between 2003 and 2004. After excluding 13 patients absolutely breast-fed and 2 patients transferred from other hospitals with the impression of CMPIE, the 86 study subjects were divided into three groups based on the underlying etiologies; CMPIE, infectious and non-infectious group.RESULTS:
CMPIE was diagnosed in 11 patients (12.8%). On admission, failure to gain weight (P= 0.003), hypoalbuminemia (P=0.003), peripheral leukocytosis (P=0.015), and metabolic acidosis (P=0.014) were more significant in the CMPIE group than in the others. Multiple logistic regression analysis showed that the independent predictors of high risks for CMPIE were failure to gain weight < 10 g/day (OR, 10.25[95% CI, 1.62-65.06]) and serum hypoalbuminemia < 3.5 g/dL (OR, 9.18[95% CI, 1.69- 49.74]). Cow's milk challenges were performed in the 11 CMPIE patients; vomiting (81.8%), abnormal stool test (80.0%), peripheral leukocyte count and absolute neutrophil count (ANC) increase (100.0%) (P< 0.05), and enteropathy (100.0%).CONCLUSION:
CMPIE is not a rare clinical disease in early infancy. The high risk factors of CMPIE were identified as follow failure to gain weight below 10 g/day, hypoalbuminemia on admission and a rapid decrease during admission. Cow's milk challenge test with endoscopic duodenal biopsy was helpful to confirm CMPIE.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Acidosis
/
Vomiting
/
Biopsy
/
Logistic Models
/
Risk Factors
/
Hypoalbuminemia
/
Milk
/
Diarrhea
/
Enterocolitis
/
Hypersensitivity, Delayed
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2005
Type:
Article
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