Effect of terazosin on blood pressure and serum lipids in nild to moderate hypertension
Korean Circulation Journal
;
: 454-460, 1993.
Article
in Korean
| WPRIM
| ID: wpr-115425
ABSTRACT
BACKGROUND:
We evaluated the antihypertensive effect, safety and effect on serum lipids of terazosin, second generation alpha1-blocker.METHODS:
Terazosin 1-4mg was adminstered once daily in 20 patients for 12 weeks with dose titration every 2 weeks.RESULTS:
1) The systolic and diastolic blood pressure were decreased from 170.0+/-13.0/104.0+/-6.0mmHg to 144.0+/-13.3/88.0+/-5.6mmHg(p<0.01), but the heart rate and body weight were independant of terazosin administration. 2) Total cholesterol was decreased significantly from 209.9+/-33.5mg/dL to 194.6+/-30.1mg/dL after 12 weeks treatment(p<0.05), triglyceride was decreased significantly from 185.4+/-37.0mg/dL to 168.9+/-35.0mg/dL(p<0.05). and LDL-cholesterol was decreased significantly from 134.5+/-31.9mg/dL to 122.7+/-29.9mg/dL(p<0.05), but HDL-cholesterol was increased significantly from 37.8+/-5.6mg/dL to 40.6+/-5.5mg/dL(p<0.05). 3) The adverse effects of terazosin were dizziness in 2, headache in 2, asthenia in 1, peripheral edema in 1 and skin rash in 1 patient, but were not troublesome enough to stop medication.CONCLUSIONS:
Terazosin 1-4mg once daily regimen was effective and safe as an antihypertensive agent, and moreover terazosin has favorable effects on serum lipids.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthenia
/
Triglycerides
/
Blood Pressure
/
Body Weight
/
Cholesterol
/
Dizziness
/
Edema
/
Exanthema
/
Headache
/
Heart Rate
Limits:
Humans
Language:
Korean
Journal:
Korean Circulation Journal
Year:
1993
Type:
Article
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