Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
;
: 6-9, 2011.
Article
in English
| WPRIM
| ID: wpr-115525
ABSTRACT
OBJECTIVE:
To investigate a kallikrein-related peptidase 2 (KLK2) single nucleotide polymorphism (SNP) in relation to male infertility because of its role in semen processing. We investigated the genetic association of the KLK2+255G>A genotype with male infertility.METHODS:
We genotyped the SNP site located in intron 1 (+255G>A, rs2664155) of KLK2 from 218 men with male infertility (cases) and 220 fertile males (controls). Pyrosequencing analysis was performed for the genotyping.RESULTS:
The SNP of the KLK2 gene had a statistically significant association with male infertility (p<0.05). The odds ratio for the minor allele (+255A) in the pooled sample was 0.47 (95% confidence intervals, 0.26-0.85) for rs2664155.CONCLUSION:
The relationship of KLK2 SNP to male infertility is statistically significant, especially within the non-azoospermia group. Further study is needed to understand the mechanisms associated with male infertility.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Semen
/
Introns
/
Odds Ratio
/
Polymorphism, Single Nucleotide
/
Alleles
/
Genetic Association Studies
/
Genotype
/
Infertility, Male
Type of study:
Etiology study
Limits:
Humans
/
Male
Language:
English
Journal:
Clinical and Experimental Reproductive Medicine
Year:
2011
Type:
Article
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