Whole pelvic intensity-modulated radiotherapy for high-risk prostate cancer: a preliminary report
Radiation Oncology Journal
;
: 199-205, 2013.
Article
in English
| WPRIM
| ID: wpr-115567
ABSTRACT
PURPOSE:
To assess the clinical efficacy and toxicity of whole pelvic intensity-modulated radiotherapy (WP-IMRT) for high-risk prostate cancer. MATERIALS ANDMETHODS:
Patients with high-risk prostate cancer treated between 2008 and 2013 were reviewed. The study included patients who had undergone WP-IMRT with image guidance using electronic portal imaging devices and/or cone-beam computed tomography. The endorectal balloon was used in 93% of patients. Patients received either 46 Gy to the whole pelvis plus a boost of up to 76 Gy to the prostate in 2 Gy daily fractions, or 44 Gy to the whole pelvis plus a boost of up to 72.6 Gy to the prostate in 2.2 Gy fractions.RESULTS:
The study cohort included 70 patients, of whom 55 (78%) had a Gleason score of 8 to 10 and 50 (71%) had a prostate-specific antigen level > 20 ng/mL. The androgen deprivation therapy was combined in 62 patients. The biochemical failure-free survival rate was 86.7% at 2 years. Acute any grade gastrointestinal (GI) and genitourinary (GU) toxicity rates were 47% and 73%, respectively. The actuarial rate of late grade 2 or worse toxicity at 2 years was 12.9% for GI, and 5.7% for GU with no late grade 4 toxicity.CONCLUSION:
WP-IMRT was well tolerated with no severe acute or late toxicities, resulting in at least similar biochemical control to that of the historic control group with a small field. The long-term efficacy and toxicity will be assessed in the future, and a prospective randomized trial is needed to verify these findings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pelvis
/
Prostate
/
Prostatic Neoplasms
/
Survival Rate
/
Cohort Studies
/
Prostate-Specific Antigen
/
Radiotherapy, Intensity-Modulated
/
Cone-Beam Computed Tomography
/
Neoplasm Grading
Type of study:
Controlled clinical trial
/
Etiology study
/
Practice guideline
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Radiation Oncology Journal
Year:
2013
Type:
Article
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