Clinical features of vaccination-associated thrombocytopenic purpura in children / 소아과
Korean Journal of Pediatrics
;
: 610-615, 2008.
Article
in Korean
| WPRIM
| ID: wpr-115581
ABSTRACT
PURPOSE:
Idiopathic thrombocytopenic purpura (ITP) is a relatively common hematological disease in children. It generally occurs after exposure to a common viral infection episode; however, it may occasionally follow immunization with measles, measles-mumps-rubella (MMR), hepatitis B (HBV), influenza, diphtheria-tetanus-pertussis (DTP), or chickenpox vaccines. In this study, the incidence, clinical characteristics, and treatment outcome of vaccination-associated ITP were investigated and compared with non-vaccination-associated ITP.METHODS:
The admission records of 105 pediatric ITP patients between 0-14 years of age admitted to Department of Pediatrics, Wonkwang University Hospital from January 1994 to July 2007 were retrospecitively reviewed. Patients were grouped into a vaccination-associated group and a non-vaccination-associated group according to vaccination history within the previous 1 month, and various clinical features between the two groups were statistically analyzed.RESULTS:
Thirteen patients (12%) had a preceding vaccination. Eight had received DTP vaccination, 2 had received hepatitis B, and 1 each had received influenza, MMR, and Japanese B encephalitis vaccination. However, none of the patients had a recurrent thrombocytopenia after subsequent vaccinations. In the vaccination-associated group, the age was significantly lower, anemia was more common, and the risk period with blood platelet count <20x10(9)/L was significantly shorter than for the in non-vaccination-associated group. Also, wet purpura was less prominent and the remission within 1month was more frequently achieved in the vaccination-associated ITP group.CONCLUSION:
Vaccination-associated ITP patients showed mild symptoms with a more benign and shorter lasting course than non-vaccination-associated ITP patients. Moreover, platelet count assessment at the time of the next immunization may not be necessary.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pediatrics
/
Platelet Count
/
Purpura
/
Purpura, Thrombocytopenic
/
Thrombocytopenia
/
Vaccines
/
Chickenpox
/
Incidence
/
Immunization
/
Vaccination
Type of study:
Incidence study
/
Prognostic study
Limits:
Child
/
Humans
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2008
Type:
Article
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