Transcatheter Arterial Chemoembolization Plus ¹³¹I-Labelled Metuximab versus Transcatheter Arterial Chemoembolization Alone in Intermediate/Advanced Stage Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Korean Journal of Radiology
;
: 882-892, 2016.
Article
in English
| WPRIM
| ID: wpr-115665
ABSTRACT
OBJECTIVE:
The aim of the study was to compare transcatheter arterial chemoembolization (TACE) plus ¹³¹I-labelled metuximab with TACE alone for hepatocellular carcinoma (HCC). MATERIALS ANDMETHODS:
A comprehensive search was conducted in PubMed, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Chinese BioMedical Literature Database with published date from the earliest to February 29th, 2016. No language restrictions were applied, but only prospective randomized controlled trials (RCTs) or non-RCTs were eligible for a full-text review. The primary outcome was the overall survival (OS) and effective rate (the rate of partial atrophy or complete clearance of the tumor lesion). The odds ratios (ORs) were combined using either the fixed-effects model or random-effects model.RESULTS:
Eight trials (3 RCTs and 5 non-RCTs) were included, involving a total of 1121 patients. Patients receiving combined therapy of TACE plus ¹³¹I-labelled metuximab showed significant improvement in effective rate {OR = 4.00, (95% confidence interval [CI] 2.40–6.66), p < 0.001}, 1-year OS (OR = 2.03 [95% CI 1.55–2.67], p < 0.001) and 2-year OS (OR = 2.57 [95% CI 1.41–4.66], p = 0.002].CONCLUSION:
TACE plus ¹³¹I-labelled metuximab is more beneficial for treating advanced HCCs than TACE alone in terms of tumor response and OS. Large, multi-center, and blinded randomized trials are required to confirm these findings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Atrophy
/
Odds Ratio
/
Prospective Studies
/
Radioimmunotherapy
/
Carcinoma, Hepatocellular
/
Asian People
Type of study:
Controlled clinical trial
/
Etiology study
/
Observational study
/
Risk factors
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
Korean Journal of Radiology
Year:
2016
Type:
Article
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