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Comparison of Biexponential and Monoexponential Model of Diffusion-Weighted Imaging for Distinguishing between Common Renal Cell Carcinoma and Fat Poor Angiomyolipoma
Korean Journal of Radiology ; : 853-863, 2016.
Article in English | WPRIM | ID: wpr-115668
ABSTRACT

OBJECTIVE:

To compare the diagnostic accuracy of intravoxel incoherent motion (IVIM)-derived parameters and apparent diffusion coefficient (ADC) in distinguishing between renal cell carcinoma (RCC) and fat poor angiomyolipoma (AML). MATERIALS AND

METHODS:

Eighty-three patients with pathologically confirmed renal tumors were included in the study. All patients underwent renal 1.5T MRI, including IVIM protocol with 8 b values (0–800 s/mm²). The ADC, diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) were calculated. One-way ANOVA was used for comparing ADC and IVIM-derived parameters among clear cell RCC (ccRCC), non-ccRCC and fat poor AML. The diagnostic performance of these parameters was evaluated by using receiver operating characteristic (ROC) analysis.

RESULTS:

The ADC were significantly greater in ccRCCs than that of non-ccRCCs and fat poor AMLs (each p 0.97 × 10⁻³ mm²/s, D* < 28.03 × 10⁻³ mm²/s, and f < 13.61% maximized the diagnostic sensitivity for distinguishing non-ccRCCs from fat poor AMLs. The final estimates of AUC (95% confidence interval), sensitivity, specificity, positive predictive value, negative predictive value and accuracy for the entire cohort were 0.875 (0.719–0.962), 100% (23/23), 75% (9/12), 88.5% (23/26), 100% (9/9), and 91.4% (32/35), respectively.

CONCLUSION:

The ADC and D showed similar diagnostic accuracy in distinguishing between ccRCCs and fat poor AMLs. The IVIM-derived parameters were better than ADC in discriminating non-ccRCCs from fat poor AMLs.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Perfusion / Magnetic Resonance Imaging / Carcinoma, Renal Cell / ROC Curve / Cohort Studies / Sensitivity and Specificity / Angiomyolipoma / Area Under Curve / Diffusion Magnetic Resonance Imaging / Diffusion Type of study: Diagnostic study / Etiology study / Practice guideline / Incidence study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Korean Journal of Radiology Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Perfusion / Magnetic Resonance Imaging / Carcinoma, Renal Cell / ROC Curve / Cohort Studies / Sensitivity and Specificity / Angiomyolipoma / Area Under Curve / Diffusion Magnetic Resonance Imaging / Diffusion Type of study: Diagnostic study / Etiology study / Practice guideline / Incidence study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Korean Journal of Radiology Year: 2016 Type: Article