Correlation between Clinicomorphologic Findings and Clinical Outcome in Childhood Henoch-Schonlein Purpura Nephritis
Journal of the Korean Society of Pediatric Nephrology
;
: 30-37, 2003.
Article
in Korean
| WPRIM
| ID: wpr-115891
ABSTRACT
PURPOSE:
Henoch-Schonlein purpura(HSP) is usually a self-limited disease with a good eventual outcome. The prognosis of HSP is mainly determined by the renal involvement. In this study, We evaluated children with biopsy-proven Henoch-Schonlein purpura nephritis about the clinical outcome correlated with renal manifestation and morphologic findings.METHODS:
The clinical features, initial laboratory and pathologic findings, and clinical outcome were evaluated in 60 children with biopsy-proven Henoch-Schonlein purpura nephritis at Yonsei University Severance Hospital during the period from Jan. 1990 to Dec. 2002.RESULTS:
The ratio of male to female patients was 1.21. The interval between the onset of Henoch-Schonlein purpura and renal manifestation was less than 3 months in 81% of the patients. Initial renal manifestation was microscopic hematuria in 100% of patients, isolated hematuria in 15%, acute nephritic syndrome in 7%, nephrotic syndrome in 22% of patients. Renal manifestation correlated with clinical outcome. Grade II and III were the most common in histologic grades of ISKDC. Renal pathologic finding correlated with clinical outcome.CONCLUSION:
Renal manifestation and pathologic findings correlated with the clinical outcome. It is necessary to evaluate the correlation between pathologic findings and treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
IgA Vasculitis
/
Hematuria
/
Nephritis
/
Nephrotic Syndrome
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Child
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Society of Pediatric Nephrology
Year:
2003
Type:
Article
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