Glucose-Dependent Insulinotropic Peptide Level Is Associated with the Development of Type 2 Diabetes Mellitus
Endocrinology and Metabolism
;
: 134-141, 2016.
Article
in English
| WPRIM
| ID: wpr-116060
ABSTRACT
BACKGROUND:
Incretin hormone levels as a predictor of type 2 diabetes mellitus have not been fully investigated. Therefore, we measured incretin hormone levels to examine the relationship between circulating incretin hormones, diabetes, and future diabetes development in this study.METHODS:
A nested case-control study was conducted in a Korean cohort. The study included the following two groups the control group (n=149), the incident diabetes group (n=65). Fasting total glucagon-like peptide-1 (GLP-1) and total glucose-dependent insulinotropic peptide (GIP) levels were measured and compared between these groups.RESULTS:
Fasting total GIP levels were higher in the incident diabetes group than in the control group (32.64±22.68 pmol/L vs. 25.54±18.37 pmol/L, P=0.034). There was no statistically significant difference in fasting total GLP-1 levels between groups (1.14±1.43 pmol/L vs. 1.39±2.13 pmol/L, P=0.199). In multivariate analysis, fasting total GIP levels were associated with an increased risk of diabetes (odds ratio, 1.005; P=0.012) independent of other risk factors.CONCLUSION:
Fasting total GIP levels may be a risk factor for the development of type 2 diabetes mellitus. This association persisted even after adjusting for other metabolic parameters such as elevated fasting glucose, hemoglobin A1c, and obesity in the pre-diabetic period.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Gastric Inhibitory Polypeptide
/
Case-Control Studies
/
Multivariate Analysis
/
Risk Factors
/
Cohort Studies
/
Fasting
/
Diabetes Mellitus, Type 2
/
Glucagon-Like Peptide 1
/
Incretins
/
Glucose
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Endocrinology and Metabolism
Year:
2016
Type:
Article
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