Assessment of the Viable Fraction of Hepatocytes by Mangafodipir Trisodium Enhanced Functional MR Imaging: Preliminary Report in Animal Models
Journal of the Korean Radiological Society
;
: 161-170, 2007.
Article
in English
| WPRIM
| ID: wpr-11609
ABSTRACT
PURPOSE:
We designed this study to evaluate the feasibility of using mangafodipir trisodium enhanced functional liver imaging (MT-FLI) for assessing the viable fraction of hepatocytes (VFH) in the liver. MATERIALS ANDMETHODS:
We evaluated the change of VFH with using MT-FLI before and after inducing acute hepatic necrosis (AHN) with CCl4 in the liver of 15 beagle dogs. The MR imaging was performed on a 1.5T MRI unit with using the EFGRE-3D sequence (TR/TE=4.7/1.1 msec; flip angle 20.0degree). We evaluated the linear dependence of the density of viable hepatocytes in AHN on the MR images as compared to that in the corresponding normal livers (DAHN/DN) on the VFH in their pathologic specimens, and the change of the VFH from the MT-FLI on that of the laboratory findings (AST, ALT, albumin, bilirubin, PT, ICG-R15) before and after AHN induction.RESULTS:
The mean+/-SD of the VFH from the MT-FLI in AHN was 61.2+/-10.7% of that of the normal ones. The DAHN/DN showed strong positive linear dependence on the VFH in their pathologic specimens (β=.769, p.938, p<.05).CONCLUSION:
The MT-FLI seems to be a feasible method for measuring VFH in the liver.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bilirubin
/
Magnetic Resonance Imaging
/
Hepatocytes
/
Models, Animal
/
Liver
/
Necrosis
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Journal of the Korean Radiological Society
Year:
2007
Type:
Article
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