E6 Oncoprotein Expression in Non-Small Cell Lung Cancer Patients / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 349-354, 2011.
Article
in Korean
| WPRIM
| ID: wpr-116310
ABSTRACT
BACKGROUND:
Lung cancer is the leading cause of cancer deaths in the world. Human papillomavirus (HPV) infection and E6 oncoprotein expression are known risk factors for the development of non-small cell lung cancer (NSCLC). This study was performed to evaluate the prevalence of HPV 16/18 E6 oncoprotein expression in patients with NSCLC.METHODS:
Immunohistochemical stains of the HPV 16/18 E6 oncoprotein were performed in tumor tissues from 68 patients with NSCLC who underwent curative surgery from March 2006 to November 2008.RESULTS:
The E6 oncoprotein was expressed in 29.4%of patients with NSCLC and a statistical analysis revealed that E6 oncoprotein expression was significantly higher in females (p=0.028), never smokers (p=0.045), and patients with adenocarcinoma (p=0.022) than that in other patients.CONCLUSION:
The E6 oncoprotein was expressed in 29.4% of patients with NSCLC. Further studies detecting HPV infection and E6 oncoprotein expression in never smoking patients with NSCLC are needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Smoke
/
Adenocarcinoma
/
Smoking
/
Oncogene Proteins, Viral
/
Prevalence
/
Risk Factors
/
Carcinoma, Non-Small-Cell Lung
/
Coloring Agents
/
Lung Neoplasms
Type of study:
Etiology study
/
Prevalence study
/
Risk factors
Limits:
Female
/
Humans
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2011
Type:
Article
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