Hyper-homocysteinemia Inducing Hyperuricemia: What are the Mechanisms?
Journal of Rheumatic Diseases
;
: 127-130, 2017.
Article
in English
| WPRIM
| ID: wpr-116476
ABSTRACT
Hyperuricemia is related to metabolic syndrome, and is defined as an over-production or under-excretion of uric acid (UA), with increased UA serum concentration. Among other causes, Hyper-homocysteinemia (H-Hcy) can be responsible for hyperuricemia. The mechanisms underlying the association between these two conditions are unclear, but increased UA serum levels can be a consequence of renovascular atherosclerosis, with reduced UA excretion. An alternative hypothesis is the over-production of UA from adenosine (originating from S-adenosyl-homocysteine). Genetic polymorphism (C677T) of methylenetetrahydrofolate reductase (MTHFR) may contribute. A possible mechanism is purines biosyinthesis originating from this gene variant. However, the results obtained from several studies and meta-analyses of the relationship between H-Hcy and hyperuricemia are ambivalent, and broader research is needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Purines
/
Uric Acid
/
Adenosine
/
Hyperuricemia
/
Methylenetetrahydrofolate Reductase (NADPH2)
/
Atherosclerosis
/
Homocysteine
Language:
English
Journal:
Journal of Rheumatic Diseases
Year:
2017
Type:
Article
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