Collapsing Glomerulopathy in Renal Allograft: Case Report / 대한이식학회지

ABSTRACT

Collapsing glomerulopathy (CG) is a recently described form of focal segmental glomerulosclerosis (FSGS) which was defined by renal pathology findings. CG is characterized by severe proteinuria and rapid progressive decline of renal function clinically. We experienced one case of CG in renal allograft. 24 year-old male recipient was admitted for evaluation of proteinuria (5.08 g/day) and increment of serum creatinine level at post-transplant 150 days. The graft biopsy was taken and the pathology specimen demonstrated a typical characteristics of CG such as glomerular capillary collapse, visceral epithelial hypercellularity, deposition of immunoglobulin/C3 and variable degree of tubulointerstitial injury. The patient was negative for HIV infection before transplantation and at the time of biopsy diagnosis. No specific treatment for CG was performed. The patient progressed to the graft failure and returned to hemodialysis 84 days after biopsy. In conclusion, recognition of CG by graft biopsy is important because it is a lesion with a high risk for rapid progression to graft failure.