Difference in Resistance to Streptococcus pneumoniae Infection in Mice / 한국실험동물학회지
Laboratory Animal Research
;
: 91-98, 2011.
Article
in English
| WPRIM
| ID: wpr-116723
ABSTRACT
Streptococcus pneumoniae is a major pathogen that causes various diseases, including pneumonia and sepsis, as millions of people suffer from S. pneumoniae infection worldwide. To better understand the immune and inflammatory responses to S. pneumoniae, we produced murine models. To investigate the differences between intranasal and intratracheal infection, BALB/c mice were infected with S. pneumoniae D39 intranasally or intratracheally. Mice showed no significant differences in survival rates, body weight changes, and bacterial loads. To investigate resistance and susceptibility among mouse strains, BALB/c, C57BL/6J, tumor necrosis factor-alpha (TNF-alpha) knockout, and interleukin-10 (IL-10) knockout mice were infected with S. pneumoniae D39 via intranasal or intravenous routes. In this study, BALB/c and C57BL/6J mice were resistant, IL-10 knockout mice were intermediate, and TNF-alpha knokout mice were susceptible to S. pneumoniae infection. These data show that intranasal and intratracheal infection induced similar results after S. pneumoniae infection, and the genetic background of mice must be considered when studying S. pneumoniae infection in vivo.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumococcal Infections
/
Pneumonia
/
Streptococcus
/
Streptococcus pneumoniae
/
Body Weight Changes
/
Survival Rate
/
Tumor Necrosis Factor-alpha
/
Interleukin-10
/
Mice, Knockout
/
Sepsis
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Laboratory Animal Research
Year:
2011
Type:
Article
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